5 research outputs found
Project Pele: Humanoid Robotic Programming -A Study in Artificial Intelligence
In the ever changing world of technology, the humanoid robot has been a constant member of science fiction culture. Our project goal was to develop a humanoid robot capable of independently displaying effective soccer skills. We divided the tasks into two teams; one designed a ball kicking robot program while the other designed a path tracking robot program. After each group completed their four major objectives, we had created a superior program than its predecessors. Using our optimized code as a foundation, another group can further develop these robot programs to demonstrate even more humanlike soccer skills
Why Do Humans Imagine Robots?
This project analyzes why people are intrigued by the thought of robots, and why they choose to create them in both reality and fiction. Numerous movies, literature, news articles, online journals, surveys, and interviews have been used in determining the answer
Project Pele: Humanoid Robotic Programming - A Study in Artificial Intelligence
In the ever changing world of technology, the humanoid robot has been a constant member of science fiction culture. Our project goal was to develop a humanoid robot capable of independently displaying effective soccer skills. We divided the tasks into two teams; one designed a ball kicking robot program while the other designed a path tracking robot program. After each group completed their four major objectives, we had created a superior program than its predecessors. Using our optimized code as a foundation, another group can further develop these robot programs to demonstrate even more humanlike soccer skills
Project Pele: Humanoid Robotic Programming A Study in Artificial Intelligence
In the ever changing world of technology, the humanoid robot has been a constant member of science fiction culture. Our project goal was to develop a humanoid robot capable of independently displaying effective soccer skills. We divided the tasks into two teams; one designed a ball kicking robot program while the other designed a path tracking robot program. After each group completed their four major objectives, we had created a superior program than its predecessors. Using our optimized code as a foundation, another group can further develop these robot programs to demonstrate even more humanlike soccer skills
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated